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Postdoctoral Fellow (f/m) Immunology at Institute for Clinical Medicine
Veröffentlicht am(vor 583 Tagen)
University of OsloOslo (Norwegen)
Two Postdoctoral Fellows – immunology, B cell malignancy KG Jebsen Centre for B cell malignancies, Institute for Clinical Medicine, University of Oslo
Two three-year postdoc positions (SKO 1352) are available at the KG Jebsen Centre for B cell malignancies at the Dept of Immunology in the research group headed by Prof Ludvig A Munthe and cohosted by Hilde Schjerven (Researcher at Oslo University Hospital and Ass. Prof at UCSF, CA, USA) and Anders Tveita (Researcher at Oslo University Hospital).
The Centre studies how dysregulated interactions between Th cells and other microenvironmental components play a role in the pathogenesis and progression of B cell malignancies in human patients. We 1) define how the tumor microenvironment supports malignant B cells, 2) we establish the drug sensitivity of primary cancer cells in a personalized medicine setting, 3) we study the role and significance of transcriptional regulation and altered transcriptomes in B-cell malignancies, 4) we develop novel biologics together with biotech partners, and 5) we study pathogenesis of primary B cell malignancies in human->mouse xenografted mice or in novel gene knockout mice.
We seek highly motivated individuals holding a PhD or M.D.-PhD degree that appreciate working in an international and interactive environment. Qualification requirements include a completed PhD and experience within the field of molecular biology, cancer biology, hematology, tumor immunology, translational medicine or related fields.
The positions are three-year postdocs on human B cell malignancies, these particular positions will work with CLL, B-ALL and MM. Position 1 will study how cells in the microenvironment can support the growth of malignant B cells, with focus on antigen-specific T cells. Results will be linked to ongoing studies to define the interaction partners and transcription regulation. Position 2 will study transcriptional regulation of malignant B cells and the interaction of these factors with cell signaling pathways and also drug sensitivity assays. The postdoc will also follow up current CAR T cells in pipeline.
The postdocs will continue utilizing our technical breakthroughs that include in vitro culture of primary human cells, mimicking the microenvironment and xenografting into NSG mice, advanced flow cytometry with bar coding and multi-parameter (20-plexed) phosphoflow, RNAseq, ChIPSeq, and work with mouse models. Experience in flow cytometry and cell culture techniques is required. Experience with mass spectrometer flow cytometry (CyTOF 2), mouse research and/or bioinformatics/NGS sequencing is an advantage.
The postdocs will work in our 13 person group that will be expanded to include 5 new positions within the year. We have ongoing collaborative projects both locally in Oslo and internationally.
An important objective for the University for appointments such as these is to qualify researchers for work in top academic positions within their respective area of study.
Applications should include a cover letter summarizing the applicant's motivation, career, past research accomplishments and that describes how the applicant would fit the call (1-2 pages). In addition, a CV and a list of publications, copies of PhD-certificates, and names and contact info of three references must be included. Please also indicate the preferred position 1 or 2.
The successful applicant will work in an interactive multidisciplinary Centre of scientists, in a strong academic environment, focusing on immune dysregulation crosstalk with the microenvironment, and signaling pathways and their outcomes in B cell malignancy.
We are looking for highly motivated and structured candidates with excellent laboratory skills and good collaborative qualities.
The candidate must be fluent in written and spoken English.
A challenging and friendly working environment
Salary based on salary level 57-65 (490 900 NOK [approx 51 000 Euro]– 569 000 NOK [approx 59 000 Euro], depending on qualifications).
Favorable pension arrangement
Attractive welfare benefits
How to apply
The application must include:
Application letter, including a ½ page motivation statement and research interests
CV (summarizing education, positions, academic work-scientific publications and other relevant activity)
Copies of educational certificates and letters of recommendation
List of publications and academic work that the applicant wishes to be considered by the evaluation committee. Note: Applicants are advised not to attach the publications themselves. They should only provide a list.
Names and contact details of 2-3 referees (name, relation to candidate, e-mail and telephone number).
The application with the required attachments should preferably constitute as few files as possible, preferably 1-2 files.
The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their University‘s grading system. Please note that all documents should be in English (or a Scandinavian language).
Interviews with the best qualified candidates will be arranged.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.
Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.
No one can be appointed for more than one specified period at the same institution. According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.
The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.
According to the Norwegian Freedom of Information Act (offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The University of Oslo has an Acquisition of Rights Agreement for all employees for the purpose of securing intellectual property rights to research results etc.
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