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Structural Biology Scientist (f/m/d) for protein purification
Forschungszentrum Jülich GmbH
As a member of the Helmholtz Association, Forschungszentrum Jülich makes an effective contribution to solving major challenges facing society in the
fields of information, energy, and bioeconomy. It focuses on varied tasks in the area of research management and utilizes large, often unique, scientific infrastructure.
Come and work with around 5,900 colleagues across a range of topics and disciplines at one of Europe's largest research centres.
The Ernst Ruska-Centre (ER-C) at the Forschungszentrum Jülich houses some of the world's most advanced electron microscopes and tools for nanocharacterisation.
The scientific research covers current issues in condensed matter physics and from now on cryo-EM on biomacromolecules and in the future development of electron
microscopy. The ER-C has a total of 13 electron microscopes including the PICO FEI Titan with a point resolution of 0.5 A. The facility has been extended with
state-of-the-art cryo-microscopes FEI Talos Arctica including Bioquantum K3 and FEI Talos 120. The Structural Biology subinstitute of the ER-C investigates the
structural and molecular mechanism of autophagy and pushes the development of cryo-EM related methodology. The Jülich campus hosts a vibrant electron microscopy,
biophysics and structural biology community.
We are looking to recruit a
Structural biology scientist for protein purification
cloning, expression and purification of recombinant proteins and macromolecular complexes
overseeing multiple expressions systems, such as E.coli, insect cell culture and human cell culture
functional and biophysical characterization of purified proteins
screening, data acquisition and structure determination of purified cryo-EM samples
university degree (master or doctorate) in physics, chemistry, biology, Computer science or related field
several years of experience in structural biology related protein purification
excellent communication and interpersonal skills as well as the ability to interact effectively with team members and users are essential
experience with multiple protein expression systems so that (s)he can help other users and establish new purification procedures for macromolecular complexes
participating in generating highly pure samples for cryo-EM structural investigation of autophagy complexes at the ER-C3 for structural biology
fluency in English is required
exciting working environment on an attractive research campus with excellent infrastructure, located between the cities of Cologne, Düsseldorf and Aachen
international and interdisciplinary working atmosphere
a comprehensive further training programme
flexible working hours and various opportunities to reconcile work and private life
limited for 2 years with possible longer-term prospects